Patterns of Nonrandom Mating Within and Across 11 Major Psychiatric Disorders

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap.

The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of molecular brain-based phenotypes across five major psychiatric disorders-autism, schizophrenia, bipolar disorder, depression, an...

‏‎thematization patterns across generic moves‎‏

‏‎in this research,the authors conducted a study comparing two groups of male and female english language learners studying in a elt institute,in terms of their performance on their achievement test including listening comprehension,vocabulary,grammar,and reading comprehension and found no significant difference between the group except in listening comprehension part of the test in which the f...

Major psychiatric disorders increase risk of mortality.

ED FROM Laursen TM, Munk-Olsen T, Nordentoft M, et al. Increased mortality among patients admitted with major psychiatric disorders: a register-based study comparing mortality in unipolar depressive disorder, bipolar affective disorder, schizoaffective disorder, and schizophrenia. J Clin Psychiatry 2007;68:899–907. Notes: Overlaps in the diagnostic groups (for example, where an individual had m...

Effective size of nonrandom mating populations.

Nonrandom mating whereby parents are related is expected to cause a reduction in effective population size because their gene frequencies are correlated and this will increase the genetic drift. The published equation for the variance effective size, Ne, which includes the possibility of nonrandom mating, does not take into account such a correlation, however. Further, previous equations to pre...

Analysis of some nonrandom mating models.